A non-invasive measurable metabolic sign of glymphatic activity in the brain

The glymphatic system is fundamental to the understanding of common diseases from multiple sclerosis to dementia. Currently, there is no non-invasive method to track the clearance of brain metabolites by the glymphatic system and thus link preclinical research with clinical research in this area. This work is the first time a non-invasive imaging method, applicable to both animals and humans, will measure brain metabolite clearance by the glymphatic system in real time.